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dc.contributor.authorRibeiro, Daniel A. [UNIFESP]
dc.contributor.authorAssis, Gerson F.
dc.identifier.citationJournal of Molecular Histology. Dordrecht: Springer, v. 39, n. 1, p. 115-119, 2008.
dc.description.abstractGlutatione S-transferases (GSTs) are a family of enzymes involved in detoxification of xenobiotics. Placental GST, known as GST-P, has been detected in tissues following exposure to carcinogenic agents being regarded a reliable biomarker of exposure and susceptibility in early phases of carcinogenesis. the aim of this study was to investigate the expressivity of GST-P positive foci in the rat tongue mucosa exposed to cigarette smoke by means of immunohistochemistry. A total of twelve male Wistar rats were distributed into two groups: negative control and experimental group exposed to cigarette smoke during 75 days. After experimental period, no histopathological changes in the tongue mucosa were evidenced in the negative control and the experimental group. However, a total of five GST-P positive foci were detected in two out of six animals exposed to cigarrette smoke. None control animals were noticed GST-P positive foci. These data indicate that expression of GST-P may reflect the carcinogenic effect of cigarette smoke as well as the genetic susceptibility of animals in relation to continuous carcinogens exposure.en
dc.relation.ispartofJournal of Molecular Histology
dc.rightsAcesso restrito
dc.subjectrat tongue mucosaen
dc.titleExpression of placental glutathione S-transferase in rat tongue mucosa exposed to cigarette smokeen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUNIFESP, Universidade Federal de São Paulo, Dept Hlth Sci, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUSP, Univ São Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru, SP, Brazil
dc.description.affiliationUnifespUNIFESP, Universidade Federal de São Paulo, Dept Hlth Sci, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
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