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|Title:||A very low dose intravenous dexamethasone suppression test as an index of glucocorticoid sensitivity|
|Authors:||Faria, Claudia Dutra Costantin|
Cobra, Jayme F.
Silva, Tatiane Sousa e
Melo, Murilo Rezende
Rocha, Mylene Neves
Hayashi, Lilian Sukusima [UNIFESP]
Faria, Thelma Gomes
Almeida, Julio Antonio de Souza e
Kater, Claudio Elias [UNIFESP]
Longui, Carlos Alberto
Universidade Federal de São Paulo (UNIFESP)
Irmandade Santa Casa Misericordia São Paulo
Fac Med Sci
Brazilian AF Acad
intravenous dexamethasone suppression test
|Citation:||Hormone Research. Basel: Karger, v. 69, n. 6, p. 357-362, 2008.|
|Abstract:||Background/Aims: the wide variability of responses to corticotherapy suggests a role for individual recognition of steroid sensitivity in order to customize treatment. Oral dexamethasone (DEX) administration may be hindered by the rate of its intestinal absorption and the liver first-passage effect. in this study we suggest that an intravenous very low dose DEX suppression test (VLD IV-DST) can be used as an index for glucocorticoid (GC) sensitivity. Methods: We evaluated 87 normal subjects: 44 prepubertal children, 23 adolescents and 20 adults with a VLD IV-DST using 20 mu g/m(2) of DEX (dose able to recognize GC sensitivity). Cortisol was initially measured at several time-points after DEX prompting us to establish its nadir and subsequent simplification of the test by measuring cortisol at baseline and after 120 min. Results: Baseline cortisol was similar in adolescents and in adults, but lower in children. There was a spectrum of individual responses in all age groups. the percent reduction of cortisol after 120 min was different in these three age groups, with median values of 44.4% in children, 25.9% in adolescents and 61.6% in adults. Conclusion: This simplified VLD IV-DST using 20 mu g/m(2) of DEX is useful to evaluate individual sensitivity to GC in different age groups. Copyright (c) 2008 S. Karger AG, Basel.|
|Appears in Collections:||Em verificação - Geral|
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