Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/30323
Title: Clinical correlations and prognostic relevance of HGF, VEGF and FGF expression in Brazilian patients with non-Hodgkin lymphoma
Authors: Etto, Leina [UNIFESP]
Lacerda, Emilio [UNIFESP]
Baiocchi, Otavio Carvalho Guimarães [UNIFESP]
Silva, Vanderleia [UNIFESP]
Dalboni, Maria Aparecida [UNIFESP]
Alves, Antonio [UNIFESP]
Silva, Maria [UNIFESP]
Vettore, Andre [UNIFESP]
Colleoni, Gisele [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: non-Hodgkin lymphomas
HGF
FGF
VEGF
angiogenesis
prognosis
Issue Date: 1-Jan-2008
Publisher: Taylor & Francis Ltd
Citation: Leukemia & Lymphoma. Abingdon: Taylor & Francis Ltd, v. 49, n. 2, p. 257-264, 2008.
Abstract: The aims of this study were to correlate HGF, VEGF and FGF serum levels and microvessel density (MVD) with cell origin, biological behavior, tumor load and prognosis in NHL. Eighty-seven consecutive previously untreated NHL patients had serum samples collected; 37 (42%) of them also had serum follow-up samples; the control group was composed of 10 healthy blood donors. Cytokine serum levels were determined by ELISA, and MVD was measured by CD34 staining in paraffin blocks. HGF mean serum level was significantly higher in both early and advanced NHL stages when compared with the control group. HGF was also significantly higher in aggressive and indolent NHL when compared with the control group. Also, mean serum level of HGF in aggressive NHL was significantly higher than in indolent NHL. Regarding International Prognostic Index (IPI), HGF mean serum level at diagnosis was significantly higher for patients with IPI 2 when compared to IPI 2. Sequential analyses of HGF, VEGF and FGF serum levels in NHL showed that serum HGF and VEGF levels decreased significantly after 6 months of treatment completion. Our findings suggest that HGF serum level is associated with tumor load and aggressiveness, and response to treatment results in a decrease in HGF serum levels in NHL patients.
URI: http://repositorio.unifesp.br/handle/11600/30323
ISSN: 1042-8194
Other Identifiers: http://dx.doi.org/10.1080/10428190701769640
Appears in Collections:Em verificação - Geral

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