Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/30186
Title: Cell death and regeneration in the midgut of the mosquito, Culex quinquefasciatus
Authors: Okuda, Kendi
Almeida, Fabio de
Mortara, Renato A.
Krieger, Henrique
Marinotti, Osvaldo
Bijovsky, A. Tania
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Calif Irvine
Keywords: Culex quinquefusciatus
mosquito
midgut
apoptosis
cell death
regenerative cell
cell differentiation
ultrastructure
Issue Date: 1-Dec-2007
Publisher: Elsevier B.V.
Citation: Journal of Insect Physiology. Oxford: Pergamon-Elsevier B.V., v. 53, n. 12, p. 1307-1315, 2007.
Abstract: Haematophagy, the utilization of blood as food, has evolved independently among insects such as mosquitoes, bedbugs, fleas, and others. Accordingly, several distinct biological adaptations have occurred in order to facilitate the finding, ingestion and digestion of blood from vertebrate sources. Although blood meals are essential for survival and reproduction of these insects, mechanical and chemical stresses are caused by the ingestion of a sizable meal (frequently twice or more times the weight of the insect) containing large amounts of cytotoxic molecules such as haem. Here we present data showing that the stresses caused by a blood meal induce cell death in the midgut epithelium of Culex quinquefasciatus mosquitoes. the process involves apoptosis, ejection of dead cells to the midgut lumen and differentiation of basal regenerative cells to replace the lost digestive cells. the basal cell differentiation in blood-fed mosquito midguts represents an additional mechanism by which insects cope with the stresses caused by blood meals. C quinquefasciatus adult females are unable to replace lost cells following a third or fourth blood meal, which may have a significant impact on mosquito longevity, reproduction and vectorial capacity. (c) 2007 Elsevier B.V. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/30186
ISSN: 0022-1910
Other Identifiers: http://dx.doi.org/10.1016/j.jinsphys.2007.07.005
Appears in Collections:Em verificação - Geral

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