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Title: Exposure to arsenic at levels found in US drinking water modifies expression in the mouse lung
Authors: Andrew, Angeline S.
Bernardo, Viviane [UNIFESP]
Warnke, Linda A.
Davey, Jennifer C.
Hampton, Thomas
Mason, Rebecca A.
Thorpe, Jessica E.
Ihnat, Michael A.
Hamilton, Joshua W.
Dartmouth Med Sch
Dartmouth Coll
Universidade Federal de São Paulo (UNIFESP)
Univ Oklahoma
Keywords: arsenic
cell cycle
drinking water
immune response
oxygen transport
Issue Date: 1-Nov-2007
Publisher: Oxford Univ Press
Citation: Toxicological Sciences. Oxford: Oxford Univ Press, v. 100, n. 1, p. 75-87, 2007.
Abstract: The mechanisms of action of drinking water arsenic in the lung and the threshold for biologic effects remain controversial. Our study utilizes Affymetrix 22,690 transcript oligonucleotide microarrays to assess the long-term effects of increasing doses of drinking water arsenic on expression levels in the mouse lung. Mice were exposed at levels commonly found in contaminated drinking water wells in the United States (0, 0.1, 1 ppb), as well as the 50 ppb former maximum contaminant level, for 5 weeks. the expression profiles revealed modification of a number of important signaling pathways, many with corroborating evidence of arsenic responsiveness. We observed statistically significant expression changes for transcripts involved in angiogenesis, lipid metabolism, oxygen transport, apoptosis, cell cycle, and immune response. Validation by reverse transcription-PCR and immunoblot assays confirmed expression changes for a subset of transcripts. These data identify arsenic-modified signaling pathways that will help guide investigations into mechanisms of arsenic's health effects and clarify the threshold for biologic effects and potential disease risk.
ISSN: 1096-6080
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Appears in Collections:Em verificação - Geral

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