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Title: C-reactive protein and features of metabolic syndrome in Brazilian women with previous gestational diabetes
Authors: Ferraz, Tania B.
Motta, Rosa S.
Ferraz, Camila Lousada
Capibaribe, Diego Moreira
Forti, Adriana C.
Chacra, Antonio R.
Diabet & Hypertens Ctr
Universidade Federal de São Paulo (UNIFESP)
Keywords: BMI
Issue Date: 1-Oct-2007
Publisher: Elsevier B.V.
Citation: Diabetes Research and Clinical Practice. Clare: Elsevier B.V., v. 78, n. 1, p. 23-29, 2007.
Abstract: Objective: C-reactive protein (CRP), an inflammatory biomarker, has been associated with the development of diabetes. Gestational diabetes (GDM) predicts type 2 diabetes (T2DM) and may be part of the metabolic syndrome (MS). Few studies have examined the association of CRP, MS and diabetes in women with previous GDM.Research design and methods: Women with previous GDM (n = 70) and randomly sampled women without previous GDM (n = 108) from the one center of the Brazilian Study of Gestational Diabetes participated in the study after 6 years of index pregnancy. Oral glucose tolerance test and anthropometry were performed. CRP levels were measured by the nephelometry. the MS was defined by the ATPIII criteria.Results: There was significant positive linear correlation between CRP levels, fasting insulin (R = 0.053) and HOMA IR (0.048) in previous GDM. Mean CRP levels were significantly higher in previous GDM group with abdominal obesity (1.227 95% CI 0.871-1.584 versus 0.597,95% CI 0.378-0.817; p = 0.001) and abnormal glucose tolerance (1.168 95% CI 0.784-1.552 versus 0.657 95% CI 0.455-0.859, p = 0.012). There were differences when considering the presence of different MS features, once the previous GDM group reported a significantly higher number of women with low HDL (74.3% versus 55.6%, p = 0.0 16) and abnormal glucose tolerance (45.7% versus 25%, p = 0.005) than the group without GDM. On average, the CRP levels were significantly higher in women with previous GDM and MS (0.918 95% CI 0.569; 1.268 versus 0.524 95% CI 0.373; 0.675, p = 0.044) than the control group.Conclusions: the data suggests that the presence of MS in women with previous GDM is associated with high levels of CRP. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
ISSN: 0168-8227
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