Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/30045
Title: GM1 ganglioside induces vasodilation and increases catalase content in the brain
Authors: Furian, Ana Flavia
Oliveira, Mauro Schneider
Royes, Luiz Fernando Freire
Fiorenza, Natalia Gindri
Fighera, Michele Rechia
Myskiw, Jociane Carvalho
Weiblen, Rudi
Rubin, Maribel Antonello
Frussa-Filho, Roberto
Mello, Carlos Fernando
Universidade Federal de Sergipe (UFS)
Univ Fed Rio Grande do Sul
Universidade Federal de São Paulo (UNIFESP)
Keywords: antioxidant
GM1 ganglioside
neurodegenerative diseases
neuroprotection
catalase
vasodilation
hippocampus
cortex
striatum
free radicals
Issue Date: 15-Sep-2007
Publisher: Elsevier B.V.
Citation: Free Radical Biology and Medicine. New York: Elsevier B.V., v. 43, n. 6, p. 924-932, 2007.
Abstract: Monosialoganglioside (GM1) is a glycosphingolipid present in most cell membranes that displays antioxidant and neuroprotective properties. GM I increases catalase activity in cerebral cortices in vivo, but the mechanisms underlying this effect of GM I are not known. in the current study we investigated the effect of GM1 (50 mg/kg, ip) on the content of hemoglobin and catalase activity of hippocampus, cortex, and striatum of rats. GM I administration increased catalase activity and hemoglobin content in brain samples after 30 min, but had no effect on blood catalase activity. GM1-induced increase in catalase activity was abolished by brain perfusion with heparinized saline. Brain catalase activity in the absence of blood, estimated by regression analysis of data from perfused and nonperfused animals, was not altered by the systemic injection of GM1. Moreover, the addition of GM1 (30 or 100 mu M) did not increase catalase activity in slices of cerebral cortex in situ, further suggesting that blood circulation is required for this effect. the GM1-induced vasodilation was confirmed in vivo, because the systemic injection of GM1 (50 mg/kg, ip) increased (1.2-1.6 times) the width of pial vessels. (c) 2007 Elsevier Inc. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/30045
ISSN: 0891-5849
Other Identifiers: http://dx.doi.org/10.1016/j.freeradbiomed.2007.05.035
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.