Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/29956
Title: Cross-priming of long lived protective CD8(+) T cells against Trypanosoma cruzi infection: Importance of a TLR9 agonist and CD4(+) T cells
Authors: Alencar, Bruna C. G. de
Araujo, Adriano F. S.
Penido, Marcus L. O.
Gazzinelli, Ricardo T.
Rodrigues, Mauricio M.
Universidade Federal de São Paulo (UNIFESP)
Fiocruz MS
Universidade Federal de Minas Gerais (UFMG)
Keywords: vaccination
Trypanosoma cruzi
amastigotes
CpG ODN
Issue Date: 10-Aug-2007
Publisher: Elsevier B.V.
Citation: Vaccine. Oxford: Elsevier B.V., v. 25, n. 32, p. 6018-6027, 2007.
Abstract: We recently described that vaccination of mice with a gluthatione S transferase fusion protein representing amino acids 261-500 of the Amastigote Surface Protein-2 efficiently cross-primed protective CD8(+) T cells against a lethal challenge with the human protozoan parasite Trypanosoma cruzi. in this study, we initially established that this protective immunity was long lived. Subsequently, we studied the importance of TLR9 agonist CpG ODN 1826, TLR4 and CD4(+) T cells for the generation of these protective CD8(+) T cells. We found that: (i) the TLR9 agonist CpG ODN 1826 improved the efficiency of protective immunity; (ii) TLR4 is not relevant for priming of specific CD8(+) T cells; (iii) CD4(+) T cells are critical for priming of memory/protective CD8(+) T cells. (c) 2007 Elsevier B.V. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/29956
ISSN: 0264-410X
Other Identifiers: http://dx.doi.org/10.1016/j.vaccine.2007.05.022
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.