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Title: Effect of the antimicrobial peptide gomesin against different life stages of Plasmodium spp.
Authors: Moreira, Cristina K.
Rodrigues, Flavia G.
Ghosh, Anil
Varotti, Fernando de P.
Miranda, Antonio
Daffre, Sirlei
Jacobs-Lorena, Marcelo
Moreira, Luciano A.
Fundacao Oswaldo Cruz
Johns Hopkins Bloomberg Sch Publ Hlth
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Keywords: antimicrobial peptide
Issue Date: 1-Aug-2007
Publisher: Elsevier B.V.
Citation: Experimental Parasitology. San Diego: Academic Press Inc Elsevier Science, v. 116, n. 4, p. 346-353, 2007.
Abstract: While seeking strategies for interfering with Plasmodium development in vertebrate/invertebrate hosts, we tested the activity of gomesin, an antimicrobial peptide isolated from the hemocytes of the spider Acanthoscurria gomesiana. Gomesin was tested against asexual, sexual and pre-sporogonic forms of Plasmodium falciparum and Plasmodium berghei parasites. the peptide inhibited the in vitro growth of intraerythrocytic forms of P. falciparum. When gomesin was added to in vitro, culture of P. berghei mature gametocytes, it significantly inhibited the exflagellation of male gametes and the formation of ookinetes. in vivo, the peptide reduced the number of oocysts of both Plasmodium species in Anopheles stephensi mosquitoes, and did not appear to affect the mosquitoes. These properties make gomesin an excellent candidate as a transmission blocking agent for the genetic engineering of mosquitoes. (c) 2007 Elsevier Inc. All rights reserved.
ISSN: 0014-4894
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