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Title: Schistosonia mansoni: Expression of Fes-like tyrosine kinase SmFes in the tegument and terebratorium suggests its involvement in host penetration
Authors: Bahia, Diana
Mortara, Renato A.
Kusel, John R.
Andrade, Luiza F.
Ludolf, Fernanda
Kuser, Paula R.
Avelar, Livia
Trolet, Jacques
Dissous, Colette
Pierce, Raymond J.
Oliveira, Guilherme
Universidade Federal de São Paulo (UNIFESP)
Fiocruz MS
Univ Glasgow
Programa Pos Grad & Pequisa
Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
Univ Lille 2
Inst Pasteur
Keywords: protein tyrosine kinase
host penetration
Issue Date: 1-Jul-2007
Publisher: Elsevier B.V.
Citation: Experimental Parasitology. San Diego: Academic Press Inc Elsevier Science, v. 116, n. 3, p. 225-232, 2007.
Abstract: Protein Tyrosine Kinases (PTKs) are important molecules in intra- and inter-cellular communication, playing a major role in signal transduction processes. We have previously identified and characterized the molecular structure of a new PTK in Schistosoma mansoni, SmFes. SmFes exhibits the characteristic features of Fes/Fps protein tyrosine kinase subfamily of which it is the first member described in helminths. Herein, we show that genes orthologous to SmFes are also present in other Schistosoma species and the transcript is detected in Schistosoma japonicum. the SmFes protein was detected at all the main life-cycle stages and was most abundant in cercariae and newly-transformed schistosomula. However, no protein was detected in schistosomula maintained in vitro for 7 days. By immunolocalization assays we showed that SmFes is particularly concentrated at the terebratorium of miracidia and tegument of cercaria and schistosomula skin-stage. These findings suggest that SmFes may play a role in signal transduction pathways involved in larval transformation after penetration into intermediate and definitive hosts. (c) 2007 Elsevier Inc. All rights reserved.
ISSN: 0014-4894
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