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Title: Expression of HOXC9 and E2F2 are up-regulated in CD133+cells isolated from human astrocytomas and associate with transformation of human astrocytes
Authors: Okamoto, Oswaldo K.
Oba-Shinjo, Sueli M.
Lopes, Luciana
Marie, Suely K. Nagahashi
Universidade Federal de São Paulo (UNIFESP)
Inst Israelita Ensino & Pesquisa Albert Einstein
Keywords: cancer stem cell
Issue Date: 1-Jul-2007
Publisher: Elsevier B.V.
Citation: Biochimica Et Biophysica Acta-gene Structure and Expression. Amsterdam: Elsevier B.V., v. 1769, n. 7-8, p. 437-442, 2007.
Abstract: Comparative analysis of cancer stem cells with their neoplastic and non-neoplastic counterparts should help better understand the underlying molecular events leading to transformation and tumor dissemination. Here, we report a molecular signature comprised by genes with exclusive aberrant expression in CD133+ cells, a reported subpopulation of tumorigenic stem-like cells, isolated from human glioblastomas. Microarrays covering 55,000 transcripts were used to compare gene expression profiles in purified subpopulations of CD133+ and CD133- GBM cells. Sixteen genes, many of which not previously associated with astrocytomas, were found aberrantly expressed in CD133+ cells, but not in CD133-, when compared with corresponding non-neoplastic controls. Up-regulation of two of such genes, E2F2 and HOXC9, was detected in a set of 54 astrocytomas of different grades and significantly associated with malignancy. Due to their distinctive expression in CD133+ cells, the use of E2F2 and HOXC9 as therapeutic targets for tumor eradication is suggested. (c) 2007 Elsevier B.V. All rights reserved.
ISSN: 0167-4781
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