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dc.contributor.authorLobo Gatti, Luciano
dc.contributor.authorBurbano, Rommel Rodriguez
dc.contributor.authorZambaldi-Tunes, Mauricio
dc.contributor.authorde-Labio, Roger Willian
dc.contributor.authorAssumpcao, Paulo Pimentel de
dc.contributor.authorCardoso-Smith, Marilia de Arruda
dc.contributor.authorMarques-Payao, Spencer Luiz
dc.identifier.citationArchives of Medical Research. New York: Elsevier B.V., v. 38, n. 5, p. 551-555, 2007.
dc.description.abstractBackground. the discovery of Helicobacter pylori offered the etiologic agent of the initiating event of the inflammatory cascade. It has been confirmed that the development of gastric cancer spans over several decades sequentially starting with the acquisition of H. pylori infection and the development of chronic gastritis. the IL-6 gene (Il-6), inflammatory cytokine and the single-nucleotide polymorphisms (SNPs) at the 5' flanking region of the Il-6 gene promoter (G or C at - 174 base and at - 572 or - 597 C or A) have been identified with increased Il-6 levels.Methods. Biopsies were collected from 168 patients. SNPs in Il-6 - 174 were analyzed by PCR-RFLP.Results. Promoter SNP of Il-6 at - 174 base were within Hardy-Weinberg equilibrium. We did not find any association between the frequencies of - 174 polymorphism with specific histological type of gastric adenocarcinoma, but the G (guanine) allele at - 174 was significantly higher in gastric adenocarcinoma than in patients with chronic gastritis.Conclusions. We observed an association between GG allele on - 174 base with gastric cancer. (c) 2007 IMSS. Published by Elsevier Inc.en
dc.publisherElsevier B.V.
dc.relation.ispartofArchives of Medical Research
dc.rightsAcesso restrito
dc.subjectinterleukin-6 polymorphismen
dc.subjectgastric canceren
dc.subjecthelicobacter pylorien
dc.titleInterleukin-6 polymorphisms, Helicobacter pylori infection in adult Brazilian patients with chronic gastritis and gastric adenocarcinomaen
dc.contributor.institutionFac Med Marilia
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFed Univ Para
dc.description.affiliationFac Med Marilia, Dipciplina Genet & Biol Mol, BR-17519050 Marilia, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, EPM, BR-04023062 São Paulo, Brazil
dc.description.affiliationFed Univ Para, Ctr Ciencias Biol, Dept Biol, BR-66059 Belem, Para, Brazil
dc.description.affiliationFed Univ Para, Hosp Univ Joao Barros Barreto, Dept Patol, BR-66059 Belem, Para, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
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