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Title: Characterization and functions of beta defensins in the epididymis
Authors: Hall, Susan H.
Yenugu, Suresh
Radhakrishnan, Yashwanth
Avellar, Maria Christina Werneck [UNIFESP]
Petrusz, Peter
French, Frank S.
Univ N Carolina
Pondicherry Cent Univ
Universidade Federal de São Paulo (UNIFESP)
Keywords: defensin
male fertility
Issue Date: 1-Jul-2007
Publisher: Medknow Publications & Media Pvt Ltd
Citation: Asian Journal of Andrology. Mumbai: Medknow Publications & Media Pvt Ltd, v. 9, n. 4, p. 453-462, 2007.
Abstract: The epididymal beta-defensins have evolved by repeated gene duplication and divergence to encode a family of proteins that provide direct protection against pathogens and also support the male reproductive tract in its primary function. Male tract defensins also facilitate recovery from pathogen attack. the beta-defensins possess ancient conserved sequence and structural features widespread in multi-cellular organisms, suggesting fundamental roles in species survival. Primate SPAG11, the functional fusion of two ancestrally independent beta-defensin genes, produces a large family of alternatively spliced transcripts that are expressed according to tissue-specific and species-specific constraints. the complexity of SPAG11 varies in different branches of mammalian evolution. Interactions of human SPAG11D with host proteins indicate involvement in multiple signaling pathways.
ISSN: 1008-682X
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