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Title: Skeletal muscle structure and function in response to electrical stimulation in moderately impaired COPD patients
Authors: Dal Corso, Simone [UNIFESP]
Nápolis, Lara Maris [UNIFESP]
Malaguti, Carla [UNIFESP]
Gimenes, Ana Cristina Oliveira [UNIFESP]
Albuquerque, André Luis Pereira de
Nogueira, Cristiano Rabelo [UNIFESP]
De Fuccio, Marcelo Bicalho
Pereira, Roberto Dias Batista [UNIFESP]
Oliveira, Acary Souza Bulle [UNIFESP]
McFarlane, Niall
Nery, Luiz Eduardo [UNIFESP]
Neder, Jose Alberto [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Univ Glasgow
Keywords: chronic obstructive pulmonary disease
electrical stimulation
skeletal muscle
Issue Date: 1-Jun-2007
Publisher: W B Saunders Co Ltd
Citation: Respiratory Medicine. London: W B Saunders Co Ltd, v. 101, n. 6, p. 1236-1243, 2007.
Abstract: Study objective: To determine the structural and functional consequences of high-frequency neuromuscular electrical stimulation (hf-NMES) in a group of moderately impaired outpatients with chronic obstructive pulmonary disease (COPD).Design: A prospective, cross-over randomized trial.Setting: An university-based, tertiary center.Patients and materials: Seventeen patients (FEV1 = 49.6 +/- 13.4% predicted, Medical Research Council dyspnoea grades II-III) underwent 6-weeks hf-NMES (50 Hz) and sham stimulation of the quadriceps femoris in a randomized, cross-over design. Knee strength was measured by isokinetic dynamometry (peak torque) and leg muscle mass (LMM) by DEXA; in addition, median cross-sectional area (CSA) of type I and fibres and capillary-fibre ratio were evaluated in the vastus lateralis. the 6-min walking distance (6MWD) was also determined.
ISSN: 0954-6111
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