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Title: Endurance training restores peritoneal macrophage function in post-MI congestive heart failure rats
Authors: Batista, M. L.
Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]
Oliveira, E. M.
Seelaender, M. C. L.
Rosa, L. F. B. P. Costa
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Mogi das Cruzes
Keywords: Pro-inflammatory cytokines
Chemotaxis index
Phagocytic capacity
Exercise adaptation
Myocardial infarction
Issue Date: 1-May-2007
Publisher: Amer Physiological Soc
Citation: Journal of Applied Physiology. Bethesda: Amer Physiological Soc, v. 102, n. 5, p. 2033-2039, 2007.
Abstract: Congestive heart failure (CHF) induces a state of immune activation, and peritoneal macrophages (M Phi s) may play an important role in the development and progression of one such condition. Moderate endurance training modulates peritoneal M Phi function. We evaluated the effect of endurance training on different stages of the phagocytic process and in the production of interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) after LPS stimulation. Either ligation of the left coronary artery or Sham operations were performed in adult Wistar rats. After 4 wk, control (Sham operated) and MI (ligation of the left coronary artery) animals were randomly assigned to either a sedentary (Sham-operated sedentary, n = 7 and MI sedentary, n = 10) or a trained group (Sham-operated trained, n = 8 and MI trained, n = 8). Trained rats ran on a treadmill (0% grade at 13-20 m/min) for 60 min/day, 5 days/wk, for 8-10 wk, whereas sedentary rats had only limited activity. Training increased maximal oxygen uptake normalized for body weight (ml . kg(-1). min(-1)), as well as skeletal muscle citrate synthase maximal activity, when compared with sedentary groups. the resident and total cell number, the chemotaxis index, and the production of TNF-alpha stimulated by LPS were significantly higher in the MI sedentary group when compared with the Sham sedentary group. Moderate endurance training reversed these alterations promoted by post-MI. These results demonstrate that moderate intensity exercise training modulates peritoneal M Phi function and induces beneficial metabolic effects in rats with post-MI CHF.
ISSN: 8750-7587
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