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Title: Higher nigrostriatal dopamine neuron loss in early than late onset Parkinson's disease? A [Tc-99m]-TRODAT-1 SPECT study
Authors: Shih, Ming Chi
Augusto Franco de Andrade, Luiz
Amaro, Edson
Felicio, Andre Carvalho
Ferraz, Henrique Ballalai
Wagner, Jairo
Hoexter, Marcelo Queiroz
Lin, Li Fu
Fu, Ying Kai
Mari, Jair Jesus
Tufik, Sergio [UNIFESP]
Bressan, Rodrigo Affonseca
Universidade Federal de São Paulo (UNIFESP)
Inst Israelita Ensino & Pesquisa Albert Einstein
Hosp Israelita Albert Einstein
Inst Nucl Energy Res
Keywords: dopamine transporter
early and late onset Parkinson's disease
Issue Date: 30-Apr-2007
Publisher: Wiley-Blackwell
Citation: Movement Disorders. Hoboken: Wiley-liss, v. 22, n. 6, p. 863-866, 2007.
Abstract: Early-onset Parkinson's disease (EOPD) is distinct from the classic late-onset PD (LOPD) because of its slower disease progression. the aim of this study was to compare dopamine neuronal loss in EOPD with that of LOPD with the same disease duration, through dopamine transporter (DAT) estimation. Fourteen patients, seven EOPD (< 50 years) and seven LOPD, matched for disease duration were scanned with [Tc-99m]-TRODAT-1-SPECT (INER-Taiwan), and were assessed with standard PD scales. EOPD patients had 34% lower striatal DAT binding potential (BP) compared with that of LOPD patients (BP = 0.29 +/- 0.12, BP = 0.44 +/- 0.12, P < 0.02) with similar PD severity. These results suggest that EOPD patients have greater dopamine density loss than LOPD patients without motor-symptom worsening. (c) 2007 Movement Disorder Society.
ISSN: 0885-3185
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