Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/2963
Title: The extracellular matrix provides directional cues for neuronal migration during cerebellar development
Authors: Porcionatto, Marimélia Aparecida [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Extracellular matrix
Central nervous system
Cerebellum
Neuron
Migration
Issue Date: 1-Mar-2006
Publisher: Associação Brasileira de Divulgação Científica
Citation: Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 39, n. 3, p. 313-320, 2006.
Abstract: Normal central nervous system development relies on accurate intrinsic cellular programs as well as on extrinsic informative cues provided by extracellular molecules. Migration of neuronal progenitors from defined proliferative zones to their final location is a key event during embryonic and postnatal development. Extracellular matrix components play important roles in these processes, and interactions between neurons and extracellular matrix are fundamental for the normal development of the central nervous system. Guidance cues are provided by extracellular factors that orient neuronal migration. During cerebellar development, the extracellular matrix molecules laminin and fibronectin give support to neuronal precursor migration, while other molecules such as reelin, tenascin, and netrin orient their migration. Reelin and tenascin are extracellular matrix components that attract or repel neuronal precursors and axons during development through interaction with membrane receptors, and netrin associates with laminin and heparan sulfate proteoglycans, and binds to the extracellular matrix receptor integrins present on the neuronal surface. Altogether, the dynamic changes in the composition and distribution of extracellular matrix components provide external cues that direct neurons leaving their birthplaces to reach their correct final location. Understanding the molecular mechanisms that orient neurons to reach precisely their final location during development is fundamental to understand how neuronal misplacement leads to neurological diseases and eventually to find ways to treat them.
URI: http://repositorio.unifesp.br/handle/11600/2963
ISSN: 0100-879X
Other Identifiers: http://dx.doi.org/10.1590/S0100-879X2006000300001
Appears in Collections:Artigo

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