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Title: The effects of ruthenium tetraammine compounds on vascular smooth muscle
Authors: Zanichelli, P. G.
Estrela, H. F. G.
Spadari-Bratfisch, Regina Celia [UNIFESP]
Grassi-Kassisse, D. M.
Franco, D. W.
Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Keywords: Ruthenium nitrosyl
NO donors
Vasodilator activity
Issue Date: 1-Mar-2007
Publisher: Elsevier B.V.
Citation: Nitric Oxide-biology and Chemistry. San Diego: Academic Press Inc Elsevier Science, v. 16, n. 2, p. 189-196, 2007.
Abstract: The time course of the relaxation effect induced by a single dose (3 x 10(-6) mol/L) of trans-[Ru(NH(3))(4)L(NO)](3+) (L = nic, 4-pic, py, imN, P(OEt)(3), SO(3)(2-), NH(3), and pz) species and sodium nitroprusside (4 x 10(-9) mol/L) was studied in aortic rings without endothelium and pre-contracted with noradrenaline (1 x 10(-6) mol/L). All the compounds induced a relaxing effect in the aortic rings, but the intensity and time of relaxation were different. Only the species where L = py, 4-pic, and P(OEt)(3) were able to induce 100% (99-100%) of the relaxing effect during the assay. trans-[Ru(NH(3))(4)(L)(NO)](3+) (L = SO(3)(2-) and NH(3)) showed the lowest relaxing effect (36 and 37%, respectively) when compared with the other compounds. Relationship was observed between the time corresponding to half of the maximum relaxation intensity observed and, respectively, k(-NO), E([Ru(NO)])(/[Ru(NO)])(0')(3+)(2+') in trans-[Ru(NH(3))(4)(L)(NO)](3+) species and E(Ru(III)/Ru(II))(0') in trans- [Ru(NH(3))(4)(L)(H(2)O)](3+) ions. These relationships strongly suggested that the NO liberation from the reduced nitrosyl complexes was responsible for the observed relaxation. (c) 2006 Elsevier Inc. All rights reserved.
ISSN: 1089-8603
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