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Title: High levels of primary antiretroviral resistance genotypic mutations and B/F recombinants in Santos, Brazil
Authors: Araripe Sucupira, Maria Cecilia
Caseiro, Marcos Montani
Alves, Katia
Tescarollo, Graziela
Janini, Luiz Mario
Sabino, Ester Cerdeira
Castelo, Adauto
Page-Shafer, Kim
Diaz, Ricardo Sobhie
Universidade Federal de São Paulo (UNIFESP)
Univ Calif San Francisco
Fundacao Prosangue
Issue Date: 1-Feb-2007
Publisher: Mary Ann Liebert Inc
Citation: Aids Patient Care and Stds. New Rochelle: Mary Ann Liebert Inc, v. 21, n. 2, p. 116-128, 2007.
Abstract: This study characterized HIV-1 among antiretroviral-naive populations presenting recent infection (RI) or long-standing infection (LSI). Sera collected from January 1999 to December 2001 at an anonymous HIV testing site in Santos, Brazil, were submitted to serologic testing algorithm for recent HIV seroconversion (STARHS). the STARHS methodology uses a combination of a sensitive and a less sensitive version of an anti-HIV enzyme immunoassay (EIA), and specimens found to be positive on the sensitive EIA and negative on the less sensitive EIA are considered to represent RI. HIV-1 V3 and pol regions of those with RI and LSI were compared. Antiretroviral resistance was defined solely by genotypic analysis. Ninety samples were evaluated representing those taken from an original cohort of 345 individuals, for whom adequate samples were available. of 90 HIV-positive individuals, 25 presented RI. Cumulatively, 36.8% of those with RI and 25% of those with LSI presented resistance to at least one antiretroviral class. in the pol and V3 regions, 47% and 53% of those with RI presented clade B viruses and B/F recombinant viruses, respectively, whereas 56.2%, 41.7%, and 2.1% of those with LSI harbored clades B, B/F, and clade C viruses, respectively. Primary resistance and the prevalence of B/F recombinants was high in this population. Monitoring HIV-1 genetic diversity is important for developing vaccines and treatment strategies.
ISSN: 1087-2914
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