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Title: Association of lipase lipoprotein polymorphisms with myocardial infarction and lipid levels
Authors: Gigek, Carolina de Oliveira
Chen, Elizabeth Suchi
Cendoroglo, Maysa Seabra
Ramos, Luiz Roberto
Quirino Araujo, Lara M.
Payão, Spencer Luiz Marques [UNIFESP]
Cardoso Smith, Marilia de Arruda
Universidade Federal de São Paulo (UNIFESP)
Keywords: elderly
high-density lipoprotein
lipoprotein lipase
LPL HindIII polymorphism
LPL S447X polymorphism
myocardial infarction
Issue Date: 1-Jan-2007
Publisher: Walter de Gruyter & Co
Citation: Clinical Chemistry and Laboratory Medicine. Berlin: Walter de Gruyter & Co, v. 45, n. 5, p. 599-604, 2007.
Abstract: Background: Lipoprotein lipase has an important role in lipid metabolism. Elevated levels of very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) are associated with increased risk of coronary artery disease and low levels of high-density lipoprotein (HDL) are potentially atherogenic. the Hindill and S447X polymorphisms of the lipoprotein lipase (LPL) gene are associated with cardiovascular disease in some populations.Methods: LPL Hindill and S447X polymorphisms were analyzed in 343 individuals of 66-97 years of age from a cohort of a Brazilian elderly longitudinal study. Allele frequencies, genotype distribution and allele association with major morbidities and with serum lipid, urea, creatinine and albumin levels were also investigated. the whole sample was genotyped by PCR-restriction fragment length polymorphism (RFLP). Descriptive statistics, logistic regression analysis and t-test were used.Results: Allele frequencies were H+=0.652 and H-0.348 for LPL Hindill and S=0.824 and X=0.176 for LPL S447X polymorphism. Both polymorphisms have frequencies similar to those in some European populations. LPL Hindill polymorphism showed significant association of the HI allele with myocardial infarction. the H- allele showed a tendency to associate with higher HDL levels. the LPL S447X S allele was associated with higher triglyceride levels.Conclusions: These findings may help to identify risk factors for subjects and families and clarify the physiopathological role of these polymorphisms in age-related diseases.
ISSN: 1434-6621
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