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Title: Do polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene affect the risk of childhood acute lymphoblastic leukemia?
Authors: Pereira, Tiago Veiga
Rudnicki, Martina
Pereira, Alexandre Costa
Pombo-de-Oliveira, Maria S.
Franco, Rendrik Franca
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Inst Nacl Canc
Fleury Res Inst
Keywords: childhood
Issue Date: 1-Dec-2006
Publisher: Springer
Citation: European Journal of Epidemiology. New York: Springer, v. 21, n. 12, p. 885-886, 2006.
Abstract: Meta-analysis has become an important statistical tool in genetic association studies, since it may provide more powerful and precise estimates. However, meta-analytic studies are prone to several potential biases not only because the preferential publication of positive'' studies but also due to difficulties in obtaining all relevant information during the study selection process. in this letter, we point out major problems in meta-analysis that may lead to biased conclusions, illustrating an empirical example of two recent meta-analyses on the relation between MTHFR polymorphisms and risk of acute lymphoblastic leukemia that, despite the similarity in statistical methods and period of study selection, provided partially conflicting results.
ISSN: 0393-2990
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