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dc.contributor.authorPereira, Tiago da Veiga [UNIFESP]
dc.contributor.authorRudnicki, Martina
dc.contributor.authorPereira, Alexandre Costa
dc.contributor.authorPombo-de-Oliveira, Maria S.
dc.contributor.authorFranco, Rendrik Franca
dc.identifier.citationCancer Epidemiology Biomarkers & Prevention. Philadelphia: Amer Assoc Cancer Research, v. 15, n. 10, p. 1956-1963, 2006.
dc.description.abstractThere is evidence supporting a role for 5-10 methylenetetra-hydrofolate reductase (MTHFR) gene variants in acute lymphoblastic leukemia (ALL). To provide a more robust estimate of the effect of MTHFR polymorphisms on the risk of ALL, we did a meta-analysis to reevaluate the association between the two most commonly studied MTHFR polymorphisms (C677T and A1298C) and ALL risk. All case-control studies investigating an association between the C677T or A1298C polymorphisms and risk of ALL were included. We applied both fixed-effects and random-effects models to combine odds ratio (OR) and 95% confidence intervals (95% CI). Q-statistic was used to evaluate the homogeneity and both Egger and Begg-Mazumdar tests were used to assess publication bias. the meta-analysis of the C677T polymorphism and risk of childhood ALL included 13 studies with a total of 4,894 individuals. Under a fixed-effects model, the TT genotype failed to be associated with a statistically significant reduction of childhood ALL risk (TT versus CT + CC: OR, 0.88; 95% CI, 0.73-1.06; P = 0.18). However, individuals homozygous for the 677T allele exhibited a 2.2-fold decrease in risk of adult ALL (TT versus CT + CC: OR, 0.45; 95% CI, 0.26-0.77; P = 0.004). in both cases, no evidence of heterogeneity was observed. No association between the A1298C variant and susceptibility to both adult and childhood ALL was disclosed. Our findings support the proposal that the common genetic C677T polymorphism in the MTHFR contributes to the risk of adult ALL, but not to the childhood ALL susceptibility.en
dc.publisherAmer Assoc Cancer Research
dc.relation.ispartofCancer Epidemiology Biomarkers & Prevention
dc.rightsAcesso aberto
dc.title5,10-methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: A meta-analysisen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionInst Nacl Canc
dc.contributor.institutionFleury Res Inst
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biochem & Mol Biol, Inst Coracao, BR-05403000 São Paulo, SP, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Clin & Toxicol Anal Dept, Fac Pharmaceut Sci, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Inst Coracao, Inst Heart, São Paulo, Brazil
dc.description.affiliationInst Nacl Canc, Div Expt Med, Rio de Janeiro, Brazil
dc.description.affiliationFleury Res Inst, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biochem & Mol Biol, Inst Coracao, BR-05403000 São Paulo, SP, Brazil
dc.description.sourceWeb of Science
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