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Title: Role of the kallikrein-kinin system in Ang-(1-7)-induced vasodilation in mesenteric arterioles of Wistar rats studied in vivo-in situ
Authors: Marangoni, R. A.
Carmona, A. K.
Passaglia, RCAT
Nigro, D.
Fortes, Z. B.
Carvalho, MHC de
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Keywords: angiotensin-(1-7)
kallikrein-kinin system
renin-angiotensin system
Issue Date: 1-Jul-2006
Publisher: Elsevier B.V.
Citation: Peptides. New York: Elsevier B.V., v. 27, n. 7, p. 1770-1775, 2006.
Abstract: Angiotensin-(1-7) [Ang-(1-7)], exerts a variety of actions in the cardiovascular system, with an important effect being vasodilation. in this work, we investigated the relationship between the vasodilatory activity of Ang-(1-7) and the kallikrein-kinin system. Intravital microscopy was used to study the vasodilation caused by Ang-(1-7) in the mesenteric vascular bed of anesthetized Wistar rats. the topical application of Ang-(1-7) caused vasodilation of mesenteric arterioles that was reduced by A-779, JE 049 and peptidase inhibitors (aprotinin, SBTI, PKSI 527, E-64, PMSF). These results indicated that the vasodilation induced by Ang-(1-7) in the mesenteric arterioles of Wistar rats was heavily dependent on the activation of kallikrein and subsequent kinin formation. (c) 2006 Published by Elsevier Inc.
ISSN: 0196-9781
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Appears in Collections:Em verificação - Geral

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