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Title: Hypermethylation of CpG island in the promoter region of CALCA in acute lymphoblastic leukemia with central nervous system (CNS) infiltration correlates with poorer prognosis
Authors: Paixao, V. A.
Vidal, D. O.
Caballero, O. L.
Vettore, A. L.
Tone, L. G.
Ribeiro, K. B.
Lopes, L. F.
Ludwig Inst Canc Res
Mem Sloan Kettering Canc Ctr
Universidade de São Paulo (USP)
Fac Ciencias Med Santa Casa São Paulo
Universidade Federal de São Paulo (UNIFESP)
Keywords: ALL
Issue Date: 1-Jul-2006
Publisher: Elsevier B.V.
Citation: Leukemia Research. Oxford: Pergamon-Elsevier B.V., v. 30, n. 7, p. 891-894, 2006.
Abstract: Promoter hypermethylation occurs early in leukemogenesis and seems to be associated with poor prognosis in acute lymphoblastic leukemia (ALL). the methylation status of the promoter region of six genes was analyzed in 71 children with ALL using methylation specific PCR (MSP). Calcitonin (CALCA) and E-cadherin (CDH1) were the most frequently methylated genes in this group of patients. Considering the patients with central nervous system (CNS) infiltration, the estimated 2-year overall survival (OS) was 20% for those with methylation in CALCA promoter and 85% for those without (p=0.001). Our results suggest that the hypermethylation of CALCA promoter is a promising prognostic marker and may predict a higher risk for ALL patients with CNS infiltration. (c) 2006 Elsevier B.V. All rights reserved.
ISSN: 0145-2126
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