Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/28966
Title: Stress and cardiac beta adrenoceptors
Authors: Santos, Iraides N.
Spadari-Bratfisch, Regina C. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Keywords: beta-adrenoceptors
stress
cardiac function
adaptive responses
Issue Date: 1-Jun-2006
Publisher: Taylor & Francis Ltd
Citation: Stress-the International Journal On the Biology of Stress. Abingdon: Taylor & Francis Ltd, v. 9, n. 2, p. 69-84, 2006.
Abstract: Most modern theories about stress recognize that although stress is not a disease, it may be the trigger for the majority of diseases when allostatic overload has been generated. During stress, the glucocorticoids and catecholamines play a key role in the regulation of physiological parameters and homeostasis during stress. in the heart, positive chronotropic, inotropic, and lusitropic responses to catecholamines are mediated by various subtypes of adrenergic receptors (beta-ARs), mainly beta(1)- and beta(2)-adrenergic receptors. beta-ARs also control cardiomyocyte growth and death, thus contributing to cardiac remodelling. the structural basis of each beta-AR subtype, as well as their signalling pathways, and adaptive responses to stress are discussed. the participation of beta(3)- and putative beta(4)- ARs in the control of cardiac function is also discussed, with emphasis on low affinity beta-AR isoforms and the role they play in the response to the catecholamines under stress. the changes in beta-AR signalling under pathogenic conditions as well as under stress are reviewed.
URI: http://repositorio.unifesp.br/handle/11600/28966
ISSN: 1025-3890
Other Identifiers: http://dx.doi.org/10.1080/10253890600771858
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.