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Title: Drug-induced home cage conspecifics' behavior can potentiate behavioral sensitization in mice
Authors: Araujo, N. P.
Fukushiro, D. F.
Cunha, J. L. S.
Levin, R.
Chinen, C. C.
Carvalho, R. C.
Ribeiro, I. C. P.
Gomes, D. C.
Abilio, V. C.
Silva, R. H.
Ribeiro, R. de A.
Frussa-Filho, R.
Universidade Federal de São Paulo (UNIFESP)
Keywords: addiction
open-field behavior
social learning
Issue Date: 1-May-2006
Publisher: Elsevier B.V.
Citation: Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 84, n. 1, p. 142-147, 2006.
Abstract: The effect of home cage conspecifics' behavior on locomotor sensitization to amphetamine (AMP) or ethanol (ETOH) were investigated. Female mice were repeatedly treated with saline or AMP (2.0 mg/kg for 13 days - Experiment 1) or saline or ETOH (1.8 g/kg for 21 days - Experiment 2) in home cages where all the animals had the same treatment (homogeneous home cages - HOM-HC) or in home cages where half of the animals were drug-treated and half of them were saline-treated (heterogeneous home cages - HET-HQ. Behavioral sensitization was evaluated by the quantification of open-field locomotor activity after AMP or ETOH challenge injection, respectively. in both experiments, behavioral sensitization was potentiated in HOM-HC maintained animals. These results suggest that the behavioral sensitization phenomenon can be modified by home cage conspecifics' behavior. (c) 2006 Elsevier Inc. All rights reserved.
ISSN: 0091-3057
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