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Title: The effects of paradoxical sleep deprivation on estrous cycles of the female rats
Authors: Antunes, I. B.
Andersen, M. L.
Baracat, E. C.
Tufik, S.
Universidade Federal de São Paulo (UNIFESP)
Keywords: sleep deprivation
estrous cycle
female rat
Issue Date: 1-Apr-2006
Publisher: Elsevier B.V.
Citation: Hormones and Behavior. San Diego: Academic Press Inc Elsevier Science, v. 49, n. 4, p. 433-440, 2006.
Abstract: The present purpose was to examine how sleep deprivation affects the estrous cycle of the female rat. Paradoxical sleep-deprived (PSD) adult female Wistar rats were compared to home-cage control (CTRL) on their estrous cyclicity. Forty-four PSD and forty-four CTRL female rats were distributed into 4 subgroups of 11 animals each according to the phase of estrous cycle and were subjected to sleep deprivation for 96 h by the multiple platform technique. After PSD period, vaginal estrous cycles were taken for an additional 9 days. Animals that were submitted to PSD in diestrus phase (PSD-diestrus) had their estrous cycles disrupted during the recovery period by showing a constant diestrus during the first week. As for hormone alterations, progesterone concentrations were statistically higher in PSD-diestrus compared to respective phase control and to PSD-proestrus and PSD-estrus rats while CTRL-metestrus had higher levels than CTRL-proestrus and estrus groups. Testosterone was significantly decreased in PSD-estrus in relation to PSD-proestrus and PSD-diestrus groups and was lower in CTRL-diestrus rats than in home-cage rats in proestrus. in addition, PSD-diestrus phase exhibited higher concentrations of corticosterone and lower estrogen than the respective control rats. These data indicate that PSD may modulate the ovarian hormone release through alterations in hormonal-neurochemical mechanisms. (C) 2005 Elsevier Inc. All rights reserved.
ISSN: 0018-506X
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Appears in Collections:Em verificação - Geral

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