Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/28689
Title: Influence of pinealectomy on the amygdala kindling development in rats
Authors: Janjoppi, L.
Lacerda, AFS de
Scorza, F. A.
Amado, D.
Cavalheiro, E. A.
Arida, R. M.
Universidade Federal de São Paulo (UNIFESP)
UMC
Keywords: melatonin
pinealectomy
kindling
rat
epilepsy
Issue Date: 9-Jan-2006
Publisher: Elsevier B.V.
Citation: Neuroscience Letters. Clare: Elsevier B.V., v. 392, n. 1-2, p. 150-153, 2006.
Abstract: A considerable number of studies have demonstrated the anticonvulsant effect of melatonin. the present study examines the influence of pinealectomy on the amygdala kindling development in rats. Animals were divided into three groups: Pinealectomized rats (PNT) Sham rats (SHAM) and Control rats (CTL). the mean number of stimulations and the afterdischarge (AD) duration for each stage of kindling were similar among CTL and SHAM animals. Conversely, PNT animals showed particular characteristics during kindling development. They did not present stage I and spent a shorter time in stage 2 in relation to the CTL and SHAM animals. Consequently, the number of stimulations required to reach stage 5 was lower for the PNT group when compared to the CTL and SHAM groups. Besides, a longer AD duration during stage 5 in the PNT group was also observed. the present findings indicate that the pineal gland removal exert a significant influence on amygdala kindling development suggesting that melatonin holds potential interest in experimental therapy for epilepsy. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/28689
ISSN: 0304-3940
Other Identifiers: http://dx.doi.org/10.1016/j.neulet.2005.09.009
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.