Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/28653
Title: Comparative study of the expression of cellular cycle proteins in cervical intraepithelial lesions
Authors: Queiroz, Conceicao
Silva, Tania Correia
Alves, Venancio A. F.
Villa, Luisa L.
Costa, Maria Cecilia
Travassos, Ana Gabriela
Araujo, Jose Bouzas
Studart, Eduardo
Cheto, Tatiana
Freitas, Luiz Antonio R. de
Universidade Federal da Bahia (UFBA)
Fiocruz MS
Ludwig Inst Canc Res
Universidade Federal de São Paulo (UNIFESP)
Keywords: cervical neoplasia
p16(INK4a)
cyclin D1
Ki67
p53
Issue Date: 1-Jan-2006
Publisher: Elsevier B.V.
Citation: Pathology Research and Practice. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 202, n. 10, p. 731-737, 2006.
Abstract: Interaction of human papilloma virus oncoproteins E6 and E7 with cell cycle proteins leads to disturbances of the cell cycle mechanism and subsequent alteration in the expression of some proteins, such as p16(INK4a), cyclin DI, p53 and KI67. in this study, we compared alterations in the expression of these proteins during several stages of intra-epitelial cervical carcinogenesis. Accordingly, an immunohistochemical study was performed on 50 cervical biopsies, including negative cases and intraepithelial neoplasias. the expression patterns of these markers were correlated with the histopathological diagnosis and infection with HPV. the p16(INK4a), followed by Ki67, showed better correlation with cancer progression than p53 and cyclin DI, which recommends their use in the evaluation of cervical carcinogenesis. These monoclonal antibodies can be applied to cervical biopsy specimens to identify lesions transformed by oncogenic HPV, separating CIN 1 (p16(INK4a) positive) and identifying high-grade lesions by an increase in the cellular proliferation index (Ki67). in this way, we propose immunomarkers that can be applied in clinical practice to separate patients who need a conservative therapeutic approach from those who require a more aggressive treatment. (c) 2006 Elsevier GmbH. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/28653
ISSN: 0344-0338
Other Identifiers: http://dx.doi.org/10.1016/j.prp.2006.07.003
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