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Title: Clinical-histopathological correlation in a case of Coats' disease
Authors: Fernandes, Bruno F. [UNIFESP]
Odashiro, Alexandre N. [UNIFESP]
Maloney, Shawn
Zajdenweber, Moyses E.
Lopes, Andressa G.
Burnier, Miguel N. [UNIFESP]
McGill Univ
Henry C Witelson Ocular Pathol Lab
Universidade Federal de São Paulo (UNIFESP)
Hosp Servidores Estado
Issue Date: 1-Jan-2006
Publisher: Biomed Central Ltd
Citation: Diagnostic Pathology. London: Biomed Central Ltd, v. 1, 4 p., 2006.
Abstract: Background: Coats' disease is a non-hereditary ocular disease, with no systemic manifestation, first described by Coats in 1908. It occurs more commonly in children and has a clear male predominance. Most patients present clinically with unilateral decreased vision, strabismus or leukocoria. the most important differential diagnosis is unilateral retinoblastoma, which occurs in the same age group and has some overlapping clinical manifestations.Case presentation: A 4 year-old girl presented with a blind and painful right eye. Ocular examination revealed neovascular glaucoma, cataract and posterior synechiae. Although viewing of the fundus was impossible, computed tomography disclosed total exsudative retinal detachment in the affected eye. the eye was enucleated and subsequent histopathological evaluation confirmed the diagnosis of Coats' disease.Conclusion: General pathologists usually do not have the opportunity to receive and study specimens from patients with Coats' disease. Coats' disease is one of the most important differential diagnoses of retinoblastoma. Therefore, It is crucial for the pathologist to be familiar with the histopathological features of the former, and distinguish it from the latter.
ISSN: 1746-1596
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