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dc.contributor.authorOliveira, CSV
dc.contributor.authorHauache, O. M.
dc.contributor.authorVieira, JGH
dc.contributor.authorMaciel, RMB
dc.contributor.authorSjoroos, M.
dc.contributor.authorCanani, L. H.
dc.contributor.authorVelho, G.
dc.contributor.authorGross, J. L.
dc.contributor.authorReis, A. F.
dc.identifier.citationDiabetes & Metabolism. Moulineaux Cedex 9: Masson Editeur, v. 31, n. 6, p. 599-602, 2005.
dc.description.abstractBackground: NEUROD1 encodes a transcription factor expressed in the endocrine pancreas, and involved in beta-cell development, function and mechanisms of apoptosis. in this study, we investigated the association of a frequent polymorphism in exon 2 of NEUROD1 (G > A; Ala45Thr) with Type 1 diabetes in Brazilian subjects.Methods: A population/association study comprising 246 unrelated Type 1 diabetic and 275 nondiabetic white Brazilian subjects. the Ala45Thr variant was genotyped by a PCR-RFLP method.Results: the frequency of the Thr allele was significantly higher in patients with Type 1 diabetes than in controls (42.3% vs 35.3%, P = 0.02). Stratification by gender showed that homozygosity for the Thr allele was associated with Type 1 diabetes in women with odds ratio of 3.66 (95 % C.I. 1.43-10.11, P = 0.009) as compared to homozygosity for the Ala allele. This effect was not observed in men.Conclusions: We found a gender-specific association of the Ala45Thr variant of NEUROD1 with Type 1 diabetes in Brazilian women. Our results suggest that gender as well as ethnicity might modulate the association of NEUROD1 with Type 1 diabetes.en
dc.publisherMasson Editeur
dc.relation.ispartofDiabetes & Metabolism
dc.rightsAcesso restrito
dc.subjectType 1 diabetes mellitusen
dc.subjectNEUROD1/BETA2 geneen
dc.subjectassociation studyen
dc.titleThe Ala45Thr polymorphism of NEUROD1 is associated with type 1 diabetes in Brazilian womenen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFleury Inst
dc.contributor.institutionWallac Oy
dc.contributor.institutionHosp Clin Porto Alegre
dc.contributor.institutionUniv Fed Rio Grande Sul
dc.description.affiliationUniversidade Federal de São Paulo, Mol Endocrinol Lab, São Paulo, Brazil
dc.description.affiliationFleury Inst, São Paulo, Brazil
dc.description.affiliationWallac Oy, PerkinElmer Life & Analyt Sci, FIN-20101 Turku, Finland
dc.description.affiliationHosp Clin Porto Alegre, Div Endocrine, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Rio Grande Sul, Porto Alegre, RS, Brazil
dc.description.affiliationINSERM, U695, Paris, France
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Mol Endocrinol Lab, São Paulo, Brazil
dc.description.sourceWeb of Science
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