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|Title:||The Ala45Thr polymorphism of NEUROD1 is associated with type 1 diabetes in Brazilian women|
Hauache, O. M.
Canani, L. H.
Gross, J. L.
Reis, A. F.
Universidade Federal de São Paulo (UNIFESP)
Hosp Clin Porto Alegre
Univ Fed Rio Grande Sul
|Keywords:||Type 1 diabetes mellitus|
|Citation:||Diabetes & Metabolism. Moulineaux Cedex 9: Masson Editeur, v. 31, n. 6, p. 599-602, 2005.|
|Abstract:||Background: NEUROD1 encodes a transcription factor expressed in the endocrine pancreas, and involved in beta-cell development, function and mechanisms of apoptosis. in this study, we investigated the association of a frequent polymorphism in exon 2 of NEUROD1 (G > A; Ala45Thr) with Type 1 diabetes in Brazilian subjects.Methods: A population/association study comprising 246 unrelated Type 1 diabetic and 275 nondiabetic white Brazilian subjects. the Ala45Thr variant was genotyped by a PCR-RFLP method.Results: the frequency of the Thr allele was significantly higher in patients with Type 1 diabetes than in controls (42.3% vs 35.3%, P = 0.02). Stratification by gender showed that homozygosity for the Thr allele was associated with Type 1 diabetes in women with odds ratio of 3.66 (95 % C.I. 1.43-10.11, P = 0.009) as compared to homozygosity for the Ala allele. This effect was not observed in men.Conclusions: We found a gender-specific association of the Ala45Thr variant of NEUROD1 with Type 1 diabetes in Brazilian women. Our results suggest that gender as well as ethnicity might modulate the association of NEUROD1 with Type 1 diabetes.|
|Appears in Collections:||Em verificação - Geral|
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