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|Title:||Duplication of peri-kappa B and NF-kappa B sites of the first human immunodeficiency virus type 2 (HIV-2) transmission in Brazil|
|Authors:||Fusuma, E. E.|
Caruso, S. C.
Lopez, D. F.
Costa, L. J.
Janini, L. M.
De Mendonca, J. S.
Kallas, E. G.
Diaz, R. S.
Universidade Federal de São Paulo (UNIFESP)
Hosp Servidor Publ Estadual
|Publisher:||Mary Ann Liebert Inc|
|Citation:||Aids Research and Human Retroviruses. New Rochelle: Mary Ann Liebert Inc, v. 21, n. 11, p. 965-970, 2005.|
|Abstract:||After the identification of HIV-2 in 1986, most of the cases reported have been concentrated in West Africa. We identified a case of HIV-2 infection in São Paulo, Brazil of a 45-year-old female who presented with Pneumocystis carinii pneumonia, with a CD4 count of 22 cells/ml. DNA samples from this patient were subjected to end-point PCR amplification of the LTR region. Clones were sequenced and subjected to phylogenetic analyses. All clones were subtype A related, and four presented an insertion, corresponding to an extra NF-kappa B site. This is the first confirmed case report of an HIV-2-infected subject identified in Brazil whose transmission occurred within the country. Furthermore, the NF-kappa B duplication would potentially be associated with an increase in viral cytopathogenicity. This raises concern for the need for permanent monitoring of the spread of HIV-2 in different areas of the world, even considering its lower rate of transmission and pathogenicity when compared to HIV-1.|
|Appears in Collections:||Em verificação - Geral|
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