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Title: Validation of a rapid and reliable test for diagnosis of Chagas' disease by detection of Trypanosoma cruzi-specific antibodies in blood of donors and patients in Central America
Authors: Ponce, Carlos
Ponce, Elisa
Vinelli, Elizabeth
Montoya, Alberto
Aguilar, Vilma de
Gonzalez, Antonio
Zingales, Bianca
Rangel-Aldao, Rafael
Levin, Mariano J.
Esfandiari, Javan
Umezawa, Eufrosina S.
Luquetti, Alejandro O.
Silveira, Jose Franco da [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Secretaria Salud
Cruz Roja Hondurena
Minist Salud
Minist Salud Publ & Asistencia Social
Universidade de São Paulo (USP)
Univ Simon Bolivar
Inst Invest Engn Genet & Biol Mol
Chembio Diagnost Syst Inc
Universidade Federal de Goiás (UFG)
Issue Date: 1-Oct-2005
Publisher: Amer Soc Microbiology
Citation: Journal of Clinical Microbiology. Washington: Amer Soc Microbiology, v. 43, n. 10, p. 5065-5068, 2005.
Abstract: In this study we compared the performance of the Chagas Stat-Pak rapid immunochromatographic test with a standard enzyme-linked immunosorbent assay (ELISA) in the serodiagnosis of Chagas' disease in Central America. Out of 3,400 blood donor samples, 156 (4.6%) were positive in both assays. Three sera out of 2,084 samples from reference laboratories were negative with the rapid test but positive with the ELISA (99.8% agreement). Agreement of 100% between the two tests was observed with 339 additional sera from patients with cardiopathies and 175 sera from potential blood donors in emergency surgical cases occurring on weekends or at night. in conclusion, Chagas Stat-Pak showed 99.6% and 99.9% sensitivity and specificity, respectively, when assayed with 5,998 serum samples. It is a sensitive and specific alternative to the ELISA, as required in medical emergencies and blood screenings in Central America.
ISSN: 0095-1137
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