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|Title:||Outbreaks of cholera-like diarrhoea caused by enterotoxigenic Escherichia coli in the Brazilian Amazon Rainforest|
Luna, M. G.
Inst Oswaldo Cruz
Universidade do Estado do Rio de Janeiro (UERJ)
Univ La Habana
Universidade Federal de São Paulo (UNIFESP)
Ouro Preto Fed Univ
Leonidas & Maria Deane Res Ctr
|Publisher:||Royal Soc Tropical Medicine|
|Citation:||Transactions of the Royal Society of Tropical Medicine and Hygiene. London: Royal Soc Tropical Medicine, v. 99, n. 9, p. 669-674, 2005.|
|Abstract:||The relationship between enteropathogens and severe diarrhoea in the Brazilian Amazon is poorly understood. in 1998, outbreaks of acute diarrhoea clinically diagnosed as cholera occurred in two small villages localized far from the main cholera route in the Brazilian rainforest. PCR was performed on some enteropathogens and heat-labile (LT) and/or heat-stable (STh) toxin genes, the virulence determinants of enterotoxigenic Escherichia coli (ETEC), were detected. Further characterization of ETEC isolates revealed the presence of two clones, one from each outbreak. One presenting serotype 0167:H5 harboured LT-1 and STh toxin genes and expressed the CS5CS6 colonization factor. the other, a non-typeable serotype, was positive for the LT-I gene and expressed the CS7 colonization factor. the current study demonstrates the importance of molecular diagnosis in regions such as the Amazon basin, where the enormous distances and local support conditions make standard laboratory diagnosis difficult. Here we also show that the mis-identified cholera cases were in fact associated with ETEC strains. This is the first report of ETEC, molecularly characterized as the aetiological agent of severe diarrhoea in children and adults in the Brazilian Amazon Rainforest. (c) 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier B.V. All rights reserved.|
|Appears in Collections:||Em verificação - Geral|
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