Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/28450
Title: The importance of housing conditions on behavioral sensitization and tolerance to ethanol
Authors: Araujo, N. P.
Camarini, R.
Souza-Formigoni, MLO
Carvalho, R. C.
Abilio, V. C.
Silva, R. H.
Ricardo, V. P.
Ribeiro, R. D.
Frussa-Filho, R.
Universidade Federal de São Paulo (UNIFESP)
Keywords: ethanol
behavioral sensitization
housing
social isolation
crowding
mice
Issue Date: 1-Sep-2005
Publisher: Elsevier B.V.
Citation: Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 82, n. 1, p. 40-45, 2005.
Abstract: The differential outcomes of social isolation and crowding environment on the effects of single or repeated administration of ethanol on open-field behavior were examined in female mice. Whereas housing conditions did not alter the increase in locomotor activity induced by ethanol single administration, behavioral sensitization (a progressive increase of a drug effect following repeated drug administration) to the locomotor activating effect of ethanol was significantly greater in crowded mice as compared to isolated and control groups. Single administration of ethanol significantly decreased rearing frequency and increased immobility duration, there being tolerance to these ethanol behavior effects after repeated treatment. Social isolation attenuated the increase in immobility behavior induced by single administration of ethanol and potentiated the tolerance of ethanol-induced rearing decrease, verified after repeated treatment. These results point out that both sensitization and tolerance to the behavioral effects of ethanol can be critically influenced by housing conditions. (c) 2005 Elsevier Inc. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/28450
ISSN: 0091-3057
Other Identifiers: http://dx.doi.org/10.1016/j.pbb.2005.07.009
Appears in Collections:Em verificação - Geral

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