Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/28411
Title: Behavioral characterization of morphine effects on motor activity in mice
Authors: Patti, C. L.
Frussa, R.
Silva, R. H.
Carvalho, R. C.
Kameda, SR
Takatsu-Coleman, A. L.
Cunha, JLS
Abilio, V. C.
Universidade Federal de São Paulo (UNIFESP)
Keywords: morphine
motor behavior
open-field
mice
Issue Date: 1-Aug-2005
Publisher: Elsevier B.V.
Citation: Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 81, n. 4, p. 923-927, 2005.
Abstract: A biphasic effect of morphine on locomotion has been extensively described. Nevertheless, the effects of this opioid on other behavioral parameters have been overlooked. the aim of the present study was to verify the effects of different doses of morphine on motor behaviors observed in an open-field. Adult female mice were injected with saline or morphine (10, 15 and 20 mg/kg, i.p.) and observed in an open-field for quantification of locomotor and rearing frequencies as well as duration of immobility and grooming. the lowest dose of morphine decreased locomotion (and increased immobility duration) while the highest dose increased it. All doses tested decreased rearing and grooming. Thus, the effects of morphine on locomotion do not parallel to its effects on rearing and grooming. Our results indicate that locomotion not always reflects the effect of drugs on motor activity, which can be better investigated when other behavioral parameters are concomitantly taken into account. (c) 2005 Elsevier Inc. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/28411
ISSN: 0091-3057
Other Identifiers: http://dx.doi.org/10.1016/j.pbb.2005.07.004
Appears in Collections:Em verificação - Geral

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