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Title: The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
Authors: El-Sayed, N. M.
Myler, P. J.
Bartholomeu, D. C.
Nilsson, D.
Aggarwal, G.
Tran, A. N.
Ghedin, E.
Worthey, E. A.
Delcher, A. L.
Blandin, G.
Westenberger, S. J.
Caler, E.
Cerqueira, G. C.
Branche, C.
Haas, B.
Anupama, A.
Arner, E.
Aslund, L.
Attipoe, P.
Bontempi, E.
Bringaud, F.
Burton, P.
Cadag, E.
Campbell, D. A.
Carrington, M.
Crabtree, J.
Darban, H.
Silveira, J. F. da
Jong, P. de
Edwards, K.
Englund, P. T.
Fazelina, G.
Feldblyum, T.
Ferella, M.
Frasch, A. C.
Gull, K.
Horn, D.
Hou, L. H.
Huang, Y. T.
Kindlund, E.
Ktingbeil, M.
Kluge, S.
Koo, H.
Lacerda, D.
Levin, M. J.
Lorenzi, H.
Louie, T.
Machado, C. R.
McCulloch, R.
McKenna, A.
Mizuno, Y.
Mottram, J. C.
Nelson, S.
Ochaya, S.
Osoegawa, K.
Pai, G.
Parsons, M.
Pentony, M.
Pettersson, U.
Pop, M.
Ramirez, J. L.
Rinta, J.
Robertson, L.
Salzberg, S. L.
Sanchez, D. O.
Seyler, A.
Sharma, R.
Shetty, J.
Simpson, A. J.
Sisk, E.
Tammi, M. T.
Tarteton, R.
Teixeira, S.
Van Aken, S.
Vogt, C.
Ward, P. N.
Wickstead, B.
Wortman, J.
White, O.
Fraser, C. M.
Stuart, K. D.
Andersson, B.
Inst Genome Res
George Washington Univ
Seattle Biomed Res Inst
Univ Washington
Karolinska Inst
Univ Calif Los Angeles
Universidade Federal de Minas Gerais (UFMG)
Uppsala Univ
Adm Nacl Labs
Inst Salud ANUS
Univ Bordeaux 2
Univ Glasgow
Univ Cambridge
Universidade Federal de São Paulo (UNIFESP)
Childrens Hosp
Johns Hopkins Univ
Natl Univ San Martin
Univ Oxford
Univ London London Sch Hyg & Trop Med
Univ Massachusetts
Fundacao Oswaldo Cruz
Univ Buenos Aires
Cent Univ Venezuela
Natl Univ Singapore
Univ Georgia
Issue Date: 15-Jul-2005
Publisher: Amer Assoc Advancement Science
Citation: Science. Washington: Amer Assoc Advancement Science, v. 309, n. 5733, p. 409-415, 2005.
Abstract: Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large, families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.
ISSN: 0036-8075
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