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Title: High glucose levels abolish antiatherosclerotic benefits of ACE inhibition in alloxan-induced diabetes in rabbits
Authors: Pomaro, D. R.
Ihara, SSM
Pinto, Leonor do Espírito Santo de Almeida [UNIFESP]
Ueda, Ivete [UNIFESP]
Casarini, Dulce E. [UNIFESP]
Ebihara, Fabiana [UNIFESP]
Santos, Andreza O. [UNIFESP]
Izar, Maria Cristina de Oliveira [UNIFESP]
Fonseca, Francisco Antonio Helfenstein [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: ACE inhibitor
Issue Date: 1-Apr-2005
Publisher: Lippincott Williams & Wilkins
Citation: Journal of Cardiovascular Pharmacology. Philadelphia: Lippincott Williams & Wilkins, v. 45, n. 4, p. 295-300, 2005.
Abstract: Renin-angiotensin system activation is recognized to play an important role in atherosclerosis. This study aimed to verify the antiatherosclerotic effects of ACE inhibition on an experimental model of diabetes and hypercholesterolemia. Diabetes was induced in New Zealand male rabbits with a single dose of alloxan (100 mg/kg, IV), and, according to plasma glucose levels obtained after 1 week, the animals were divided into 2 groups (>= 250 mg/dL or < 250 mg/dL). Each group was randomly assigned to receive or not quinapril (30 mg/d) added to a 0.5% cholesterol-enriched diet. Animals with high glucose levels at 1 week and that remained high after 12 weeks presented higher triglyceride levels (P < 0.02 versus basal). Those initially hyperglycemic but presenting < 250 mg/dL glucose at the end of study formed an additional group. Plasma ACE activity was lower in quinapril-treated animals (P < 0.01 versus untreated groups). However, aorta intima/media ratio and intima area were lower only in the subgroups of quinapril-treated animals with low glucose levels (P < 0.05). Our results support the hypothesis that high plasma glucose may abolish the anti atheroscl erotic effect of ACE inhibitors.
ISSN: 0160-2446
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Appears in Collections:Em verificação - Geral

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