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Title: Chronic myeloid leukemia following kidney transplantation
Authors: Pelloso, LAF
Campos, MGV de
Nascimento, M.
Silva, MRR
Pestana, JOM
Chauffaille, MDLF
Universidade Federal de São Paulo (UNIFESP)
Keywords: chronic myeloid leukemia
chemically induced leukemia
kidney transplantation
immunossupressive drugs
Issue Date: 1-Mar-2005
Publisher: Elsevier B.V.
Citation: Leukemia Research. Oxford: Pergamon-Elsevier B.V., v. 29, n. 3, p. 353-355, 2005.
Abstract: Immunosuppressed renal recipients are at an increased risk of developing cancer. Leukemias are less frequent than other hematopoietic tumours and development of CML after immunosuppression is rare. We describe a 37-year-old male who presented with left-shifted leukocytosis, hypercellular bone marrow 32 months after the kidney transplant. G-banding karyotype revealed 46,XY,t(9;22)(q34;q11) and the diagnosis of chronic myeloid leukemia was made. This is the 13th case of CML after kidney transplant reported. Whether this CML appeared as a random phenomenon or chemically induced is a matter of debate. Some individuals might have an increased susceptibility to the effects of azathioprine. (C) 2004 Elsevier B.V. All rights reserved.
ISSN: 0145-2126
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