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Title: Evaluation of fluconazole resistance mechanisms in Candida albicans clinical isolates from HIV-infected patients in Brazil
Authors: Goldman, G. H.
Ferreira, MED
Marques, E. D.
Savoldi, M.
Perlin, D.
Park, S.
Martinez, PCG
Goldman, MHS
Colombo, A. L.
Universidade de São Paulo (USP)
Publ Hlth Res Inst
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Sep-2004
Publisher: Elsevier B.V.
Citation: Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 50, n. 1, p. 25-32, 2004.
Abstract: In this study, we describe resistance mechanisms in fluconazole-resistant isolates of C albicans isolated from AIDS patients from nine Brazilian hospitals. These mechanisms include the presence of point mutations in the ERG11 gene and overexpression of ERG11, and several genes encoding efflux pumps, as measured by quantitative real-time reverse transcriptase polymerase chain reaction. Several fluconazole-resistant strains had multiple mechanisms of resistance. Four mutations previously described, Y132F, K143R, E266D, and V4371, were identified among the strains, whereas some isolates contained more than one mutation. Fourteen novel mutations were identified. Interestingly, all Brazilian fluconazole-resistant isolates showed homozygosity at mating-type loci (MTL) associated with fluconazole resistance. This is the first comprehensive assessment at molecular level of mechanisms of fluconazole resistance in C albicans isolates from South America. (C) 2004 Elsevier Inc. All rights reserved.
ISSN: 0732-8893
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