Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/27774
Title: Exercise training changes autonomic cardiovascular balance in mice
Authors: De Angelis, K.
Wichi, R. B. [UNIFESP]
Jesus, WRA
Moreira, E. D.
Morris, M.
Krieger, E. M.
Irigoyen, M. C.
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Sao Judas Tadeu
Wright State Univ
Keywords: bradycardia
autonomic nervous system
baroreflex
blood pressure
Issue Date: 1-Jun-2004
Publisher: Amer Physiological Soc
Citation: Journal of Applied Physiology. Bethesda: Amer Physiological Soc, v. 96, n. 6, p. 2174-2178, 2004.
Abstract: Experiments were performed to investigate the influence of exercise training on cardiovascular function in mice. Heart rate, arterial pressure, baroreflex sensitivity, and autonomic control of heart rate were measured in conscious, unrestrained male C57/6J sedentary (n = 8) and trained mice (n = 8). the exercise training protocol used a treadmill (1 h/day; 5 days/wk for 4 wk). Baroreflex sensitivity was evaluated by the tachycardic and bradycardic responses induced by sodium nitroprusside and phenylephrine, respectively. Autonomic control of heart rate and intrinsic heart rate were determined by use of methylatropine and propranolol. Resting bradycardia was observed in trained mice compared with sedentary animals [ 485 +/- 9 vs. 612 +/- 5 beats/min (bpm)], whereas mean arterial pressure was not different between the groups (106 +/- 2 vs. 108 +/- 3 mmHg). Baroreflex-mediated tachycardia was significantly enhanced in the trained group (6.97 +/- 0.97 vs. 1.6 +/- 0.21 bpm/mmHg, trained vs. sedentary), whereas baroreflex- mediated bradycardia was not altered by training. the tachycardia induced by methylatropine was significantly increased in trained animals (139 +/- 12 vs. 40 +/- 9 bpm, trained vs. sedentary), whereas the propranolol effect was significantly reduced in the trained group (49 +/- 11 vs. 97 +/- 11 bpm, trained vs. sedentary). Intrinsic heart rate was similar between groups. in conclusion, dynamic exercise training in mice induced a resting bradycardia and an improvement in baroreflex- mediated tachycardia. These changes are likely related to an increased vagal and decreased sympathetic tone, similar to the exercise response observed in humans.
URI: http://repositorio.unifesp.br/handle/11600/27774
ISSN: 8750-7587
Other Identifiers: http://dx.doi.org/10.1152/japplphysiol.00870.2003
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.