Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/27737
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dc.contributor.authorAbrahao, M. S.
dc.contributor.authorMontero, EFS
dc.contributor.authorJunqueira, VBC
dc.contributor.authorGiavarotti, L.
dc.contributor.authorJuliano, Y.
dc.contributor.authorFagundes, D. J.
dc.date.accessioned2016-01-24T12:37:08Z-
dc.date.available2016-01-24T12:37:08Z-
dc.date.issued2004-05-01
dc.identifierhttp://dx.doi.org/10.1016/j.transproceed.2004.03.046
dc.identifier.citationTransplantation Proceedings. New York: Elsevier B.V., v. 36, n. 4, p. 860-862, 2004.
dc.identifier.issn0041-1345
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27737-
dc.description.abstractThe objective of this study was to evaluate the effect of ischemic preconditioning upon lesions produced by ischemia-reperfusion of the small intestine. Thirty EPM-1 Wistar rats were randomly distributed into three groups: ischemic preconditioning (IPC; n = 12), ischemia-reperfusion (I/R; n = 12), and control (C; n = 6). Laparotomy permitted isolation of the mesenteric artery for clamping. the animals were heparinized and hydrated. IPC was induced by: 10 minutes of ischemia followed by 10 minutes of reperfusion and then 50 minutes ischemia followed by another 30 minutes reperfusion. Group I/R was submitted to the same protocol except for the 20 minutes of preconditioning. Group C animals underwent only laparotomy for 100 minutes. After reperfusion small intestine fragments were examined histologically. Blood samples were obtained to measure LDH and lactate prior to euthanasia. Lactate values were significantly lower in the IPC as compared to I/R group, 39 versus 67 mg/dL, respectively (P less than or equal to .05). However, neither IPC (grade 3) lesions of the mucosa versus I/R (grade 4) nor LDH values (PCI = 680, I/R = 873 U/L) were statistically different. Thus No morphological evidence of protection was observed following ischemic preconditioning.en
dc.format.extent860-862
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofTransplantation Proceedings
dc.rightsAcesso restrito
dc.titleBiochemical and morphological evaluation of ischemia-reperfusion injury in rat small bowel modulated by ischemic preconditioningen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUNIFESP, Paulista Med Sch, Dept Surg, Santana de Parnaiba, SP, Brazil
dc.description.affiliationUNIFESP, Paulista Med Sch, Dept Med, Santana de Parnaiba, SP, Brazil
dc.description.affiliationUNIFESP, Paulista Med Sch, Dept Epidemiol, Santana de Parnaiba, SP, Brazil
dc.description.affiliationUnifespUNIFESP, Paulista Med Sch, Dept Surg, Santana de Parnaiba, SP, Brazil
dc.description.affiliationUnifespUNIFESP, Paulista Med Sch, Dept Med, Santana de Parnaiba, SP, Brazil
dc.description.affiliationUnifespUNIFESP, Paulista Med Sch, Dept Epidemiol, Santana de Parnaiba, SP, Brazil
dc.identifier.doi10.1016/j.transproceed.2004.03.046
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000222063800019
Appears in Collections:Artigo

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