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Title: Paradoxical sleep deprivation potentiates amphetamine-induced behavioural sensitization by increasing its conditioned component
Authors: Frussa, R.
Goncalves, MTM
Andersen, M. L.
Araujo, N. P. de
Chinen, C. C.
Tufik, S.
Universidade Federal de São Paulo (UNIFESP)
Keywords: paradoxical sleep deprivation
behavioral sensitization
open-field behavior
Issue Date: 2-Apr-2004
Publisher: Elsevier B.V.
Citation: Brain Research. Amsterdam: Elsevier B.V., v. 1003, n. 1-2, p. 188-193, 2004.
Abstract: The effects of paradoxical sleep deprivation (PSD-48 h) on the conditioned and unconditioned components of behavioural sensitization to amphetamine (two injections of 2.0 mg/kg, separated by 7 days) were studied using locomotion frequency of mice observed in an open-field as experimental parameter. Behavioural sensitization only occurred in PS deprived mice that were exposed to the open-field after the first amphetamine injection. the possible involvement of PSD in the development of a Pavlovian association between the stimulant effect of amphetamine and environmental as well as interoceptive drug cues is discussed. (C) 2004 Elsevier B.V. All rights reserved.
ISSN: 0006-8993
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