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Title: Role of beta(2)-glycoprotein I, LDL-, and antioxidant levels in hypercholesterolemic elderly subjects
Authors: Gomes, L. F.
Alves, A. F.
Sevanian, A.
Peres, C. D.
Cendoroglo, M. S.
De Mello-Almada, C.
Quirino, L. M.
Ramos, L. R.
Junqueira, VBC
Universidade de São Paulo (USP)
Univ So Calif
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Apr-2004
Publisher: Mary Ann Liebert Inc Publ
Citation: Antioxidants & Redox Signaling. Larchmont: Mary Ann Liebert Inc Publ, v. 6, n. 2, p. 237-244, 2004.
Abstract: The levels of electronegative low-density lipoprotein (LDL-), LDL cholesterol oxidability, and plasma levels of molecular antioxidants and of beta(2)-glycoprotein I (beta(2) GPI) were studied in a group of 10 hypercholesterolemic (HC) and 10 normocholesterolemic (NC) elderly subjects. HC subjects showed significantly higher levels of cholesterol, LDL cholesterol, LDL-, and beta(2)GPI than NC, whereas high-density lipoprotein cholesterol and alpha-tocopherol levels were lower in HC as compared with NC subjects. Correlations among LDL- levels, LDL oxidation lag time, beta(2)GPI, and antioxidant plasma levels were studied in 100 HC elderly subjects. Lag time for in vitro LDL oxidation positively correlated with ubiquinol-10 levels (p = 0.008), but not with other antioxidants studied or beta(2)GPI. LDL- and alpha-tocopherol levels showed an inverse and significant correlation (p = 0.018). beta(2)GPI and LDL cholesterol levels were correlated (p = 0.001), whereas no significance was found between LDL- and beta(2) GPI levels (p = 0.057). the physiological significance of alpha-tocopherol and ubiquinol-10 levels on LDL- levels, and the presence of high levels of beta(2)-GPI, are discussed in terms of protective mechanisms operating during the overall atherosclerosis process.
ISSN: 1523-0864
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