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Title: The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin
Authors: Dale, C. S.
Goncalves, LRC
Juliano, L.
Juliano, M. A.
Silva, AMM da
Giorgi, R.
Butantan Inst
Universidade Federal de São Paulo (UNIFESP)
Keywords: hyperalgesia
Issue Date: 1-Jan-2004
Publisher: Elsevier B.V.
Citation: Peptides. New York: Elsevier B.V., v. 25, n. 1, p. 81-89, 2004.
Abstract: The effect of a synthetic peptide (H-92-G(110)) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on hyperalgesia and edema induced by either jararhagin or papain in the rat paw. mS100A9p not only reverted hyperalgesia and edema induced by jararhagin, but also the highest concentration induced antinociception. Hemorrhage induced by jararhagin and its hydrolytic activity were inhibited by mS100A9p. These data suggest that mS100A9p might block jararhagin-induced hyperalgesia and edema by inhibiting jararhagin catalytic activity, since papain-induced hyperalgesia and edema were not inhibited by mS100A9p. (C) 2004 Elsevier Inc. All rights reserved.
ISSN: 0196-9781
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Appears in Collections:Em verificação - Geral

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