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Title: Amitriptyline eliminates calculi through urinary tract smooth muscle relaxation
Authors: Achar, Eduardo [UNIFESP]
Achar, Rosi Aparecida Nunes [UNIFESP]
Paiva, Therezinha Bandiera [UNIFESP]
Campos, Alexandre Holthausen [UNIFESP]
Schor, Nestor [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Sao Teodoro Vet Hosp
Keywords: amitriptyline
urinary tract smooth muscle
voltage-dependent potassium channel
obstructive acute renal failure
Issue Date: 1-Oct-2003
Publisher: Blackwell Publishing Inc
Citation: Kidney International. Malden: Blackwell Publishing Inc, v. 64, n. 4, p. 1356-1364, 2003.
Abstract: Background. We investigated the effects of amitriptyline in the urinary tract smooth muscle and urolithiasis.Methods. Cats presenting with obstructive acute renal failure (ARF) received amitriptyline, and renal function and survival rates were analyzed. Isometric contractions and membrane potentials of rat, pig, or human isolated urinary tract smooth muscle were recorded in the presence or absence of amitriptyline.Results. Twenty cats with obstructive ARF caused by urethral plugs received amitriptyline. in all cases, plugs were completely eliminated, and renal function returned to normal, with a 100% survival rate in the follow-up. Amitriptyline produced potent relaxations in rat urethral strips, accompanied by significant reductions in urethral ring membrane potential. This effect was prevented by pretreatment of urethral rings with 4-aminopyridine (4-AP), a voltage-dependent potassium channel blocker. Amitriptyline abolished in a reversible manner acetylcholine-, bradykinin-, and KCl-induced contractions in rat isolated bladder, and this effect was also prevented by 4-AP. of interest, spontaneous and KCl-induced contractions of pig and human isolated ureter were also blocked by amitriptyline.Conclusion. Our results indicate that amitriptyline is an effective and potent relaxant of urinary tract smooth muscle and this effect is mediated by opening of voltage dependent-potassium channels. We suggest that amitriptyline administration may help to promote elimination of urinary calculi.
ISSN: 0085-2538
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Appears in Collections:Em verificação - Geral

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