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dc.contributor.authorNucci, M.
dc.contributor.authorAnaissie, E. J.
dc.contributor.authorQueiroz-Telles, F.
dc.contributor.authorMartins, C. A.
dc.contributor.authorTrabasso, P.
dc.contributor.authorSolza, C.
dc.contributor.authorMangini, C.
dc.contributor.authorSimoes, B. P.
dc.contributor.authorColombo, Arnaldo Lopes [UNIFESP]
dc.contributor.authorVaz, J.
dc.contributor.authorLevy, C. E.
dc.contributor.authorCosta, S.
dc.contributor.authorMoreira, V. A.
dc.contributor.authorOliveira, José Salvador Rodrigues de [UNIFESP]
dc.contributor.authorParaguay, N.
dc.contributor.authorDuboc, G.
dc.contributor.authorVoltarelli, J. C.
dc.contributor.authorMaiolino, A.
dc.contributor.authorPasquini, R.
dc.contributor.authorSouza, C. A.
dc.identifier.citationCancer. Hoboken: John Wiley & Sons Inc, v. 98, n. 2, p. 315-319, 2003.
dc.description.abstractBACKGROUND. invasive infection by Fusarium sp. is associated with high mortality in patients with hematologic cancer. Yet to the authors' knowledge, little is known regarding predictors of adverse outcome.METHODS. the authors conducted a retrospective review of the records of patients with hematologic carcinoma and invasive fusariosis who were treated at one institution in the U.S. and at 11 centers in Brazil.RESULTS. the records of 84 patients were evaluated. Neutropenia was present in 83% and 33 patients had undergone stem cell transplantation. Only 18 patients (21%) were alive 90 days after the diagnosis of fusariosis. Multivariate predictors of poor outcome were persistent neutropenia (hazard ratio [HR] of 5.43; 95% confidence interval [95% Cl], 2.64-11.11) and use of corticosteroids (HR of 2.18; 95% Cl, 1.98-3.96). the actuarial survival rate of patients without any of these factors was 67% compared with 30% for patients who recovered from neutropenia but were receiving corticosteroids and 4% for patients with persistent neutropenia only. None of the patients with both risk factors survived (P < 0.0001).CONCLUSIONS. Measures to reduce the duration of neutropenia, as well as the judicious use of corticosteroids, may reduce the high mortality rate of fusariosis in patients with hematologic cancer. (C) 2003 American Cancer Society.en
dc.rightsAcesso aberto
dc.subjectprognostic factoren
dc.titleOutcome predictors of 84 patients with hematologic malignancies and Fusarium infectionen
dc.contributor.institutionUniv Arkansas Med Sci
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniv Fed Parana
dc.contributor.institutionInst Nacl Canc
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade do Estado do Rio de Janeiro (UERJ)
dc.contributor.institutionHosp Canc
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Santa Lucia
dc.contributor.institutionCtr Infantil Boldrini
dc.description.affiliationUniv Arkansas Med Sci, Myeloma & Transplantat Res Ctr, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA
dc.description.affiliationUniv Fed Rio de Janeiro, Univ Hosp, Dept Internal Med, Hematol Serv, Rio de Janeiro, Brazil
dc.description.affiliationUniv Fed Parana, Infect Dis Unit, Parana, Brazil
dc.description.affiliationInst Nacl Canc, Infect Control Serv, Rio de Janeiro, Brazil
dc.description.affiliationUniv Estadual Campinas, Bone Marrow Transplant Unit, Campinas, SP, Brazil
dc.description.affiliationUniv Estado Rio de Janeiro, Dept Internal Med, Rio de Janeiro, Brazil
dc.description.affiliationHosp Canc, Infect Control Serv, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Internal Med, Bone Marrow Transplant Unit, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Special Mycol Lab, São Paulo, Brazil
dc.description.affiliationHosp Santa Lucia, Hematol Serv, Brasilia, DF, Brazil
dc.description.affiliationCtr Infantil Boldrini, Microbiol Lab, Campinas, SP, Brazil
dc.description.affiliationUniv São Paulo, Infect Control Program, São Paulo, Brazil
dc.description.affiliationUniv Fed Parana, Bone Marrow Transplant Unit, Parana, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Bone Marrow Transplant Unit, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Special Mycol Lab, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Bone Marrow Transplant Unit, São Paulo, Brazil
dc.description.sourceWeb of Science
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