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Title: Deficiency of muscle alpha-actinin-3 is compatible with high muscle performance
Authors: Zanoteli, E.
Lotuffo, R. M.
Oliveira, ASB
Beggs, A. H.
Canovas, M.
Zatz, M.
Vainof, M.
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Harvard Univ
Keywords: muscle fiber type
marathon runners
myosin isoforms
Issue Date: 1-Feb-2003
Publisher: Humana Press Inc
Citation: Journal of Molecular Neuroscience. Totowa: Humana Press Inc, v. 20, n. 1, p. 39-42, 2003.
Abstract: Long-distance runners generally have a remarkably high proportion of slow type I fibers in their lower muscle groups. However, the transformation of type II fast fibers to slow type I fibers as a result of exercise has not been demonstrated clearly. We report the analysis of muscle type composition on m. vastus lateralis from six endurance athletes through the expression of fast, slow, and developmental myosin isoforms, and alpha-actinin-3 (ACTN3) protein. Only one among the marathon runners presented evident type I fiber predominance, and surprisingly, a second athlete showed a deficiency of ACTN3. the deficiency of ACTN3 in the muscle tissue of endurance athletes confirmed the redundancy of this protein for muscle function, even in muscles that are highly required.
ISSN: 0895-8696
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Appears in Collections:Em verificação - Geral

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