Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/27130
Title: Cocaine-induced genital reflexes during paradoxical sleep deprivation and recovery
Authors: Andersen, M. L.
Bignotto, M.
Tufik, S.
Universidade Federal de São Paulo (UNIFESP)
Keywords: paradoxical sleep deprivation
recovery
cocaine
sexual behavior
dopamine
rats
Issue Date: 1-Feb-2003
Publisher: Elsevier B.V.
Citation: Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 78, n. 2, p. 255-259, 2003.
Abstract: Paradoxical sleep deprivation (PSD) for 96 h together with cocaine administration elicits genital reflexes (penile erection [PE] and ejaculation [EJ]) in rats. Our objective was to examine genital reflexes after periods of 24, 48, 72, 96, 120, and 144 h of PSD and during a 4-day recovery period in acute cocaine-administered rats. After 24 h of PSD followed by cocaine administration, animals started to display PE and EJ, peaking in the 96th It of PSD, whereas PE and EJ were absent in control animals. the effects of more than 96 h of PSD decrease genital reflexes as observed after 120 and 144 h. Genital reflexes were present in the recovery periods but diminished gradually during the period evaluated. Even short periods of PSD probably cause supersensitivity of dopamine (DA) receptors and exacerbate the effects of cocaine on dopaminergic pathways to induce frequent PE and EJ. (C) 2002 Elsevier Science Inc. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/27130
ISSN: 0031-9384
Other Identifiers: http://dx.doi.org/10.1016/S0031-9384(02)00972-1
Appears in Collections:Em verificação - Geral

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